Description

Bromo-[[(1,1-Dimethylethoxy)Carbonyl]Amino]Acetic Acid Methyl Ester is a specialized Boc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing a bromoacetyl functional group under mild, orthogonal protection strategies, enabling precise molecular construction. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and peptide synthesis industries for developing novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Peptide Chemistry & Bioconjugation: Used to incorporate bromoacetyl handles into peptides for subsequent conjugation with thiol-containing molecules (e.g., antibodies, proteins, linkers).
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators with specific mode-of-action profiles.
• Chemical Biology Probes: Facilitates the synthesis of activity-based probes and affinity labels for studying enzyme function and protein interactions.
• Material Science: Intermediate in the synthesis of functionalized polymers and dendrimers with tailored chemical properties.
• Cross-linking Agent Precursor: The bromoacetyl moiety can be used to create homobifunctional or heterobifunctional cross-linkers for biochemical applications.

Basic Information

Product Name	Bromo-[[(1,1-Dimethylethoxy)Carbonyl]Amino]Acetic Acid Methyl Ester
CAS No.	138219-39-3
Molecular Formula	C9H16BrNO4
Molecular Weight	282.13 g/mol
Synonyms	Boc-Amino(bromo)acetic Acid Methyl Ester; Methyl 2-((tert-Butoxycarbonyl)amino)-2-bromoacetate; 2-Bromo-2-[(tert-butoxycarbonyl)amino]acetic acid methyl ester; N-Boc-2-bromoglycine methyl ester; (2-Bromo-2-{[(2-methyl-2-propanyl)oxy]carbonyl}amino)acetic Acid Methyl Ester; Bromo-N-Boc-glycine methyl ester; Boc-NH-CHBr-COOCH3
EINECS	Contact for details

Quality Control

Our Bromo-[[(1,1-Dimethylethoxy)Carbonyl]Amino]Acetic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.