Description

[(6Ar,10Ar)-1-(tert-Butyl-Dimethyl-Silanyloxy)-3-(1,1-Dimethyl-Heptyl)-6,6-Dimethyl-6A,7,10,10A-Tetrahydro-6H-Benzo[C]Chromen-9-Yl]-Methanol is a high-purity synthetic cannabinoid derivative, serving as a critical advanced intermediate in pharmaceutical research and development. Its complex molecular architecture makes it a valuable building block for the synthesis of novel therapeutic agents targeting the endocannabinoid system. This compound is essential for medicinal chemistry programs focused on neurology, pain management, and metabolic disorders, where precise chemical structure is paramount for biological activity.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel cannabinoid receptor agonists and antagonists for clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidates for potency, selectivity, and metabolic stability.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in cannabinoid-based pharmaceutical manufacturing.
• Biochemical Tool Compound: Employed in in vitro and ex vivo assays to study cannabinoid receptor signaling pathways and mechanisms of action.
• Process Chemistry Development: Utilized for scaling up synthetic routes and optimizing production processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	[(6Ar,10Ar)-1-(tert-Butyl-Dimethyl-Silanyloxy)-3-(1,1-Dimethyl-Heptyl)-6,6-Dimethyl-6A,7,10,10A-Tetrahydro-6H-Benzo[C]Chromen-9-Yl]-Methanol
CAS No.	137945-53-0
Molecular Formula	C₃₃H₅₆O₃Si
Molecular Weight	528.89 g/mol
Synonyms	9-(Hydroxymethyl)-1-[(tert-butyldimethylsilyl)oxy]-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-6,6-dimethyl-6H-dibenzo[b,d]pyran; HU-243 TBDMS Ether; 1-(tert-Butyldimethylsiloxy)-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-6,6-dimethyl-9-hydroxymethyl-6H-dibenzo[b,d]pyran; HU-243 tert-Butyldimethylsilyl Ether; Cannabinoid Derivative HU-243 TBDMS; (6aR,10aR)-1-(tert-Butyldimethylsilyloxy)-3-(1,1-dimethylheptyl)-6a,7,10,10a-tetrahydro-6,6-dimethyl-9-hydroxymethyl-6H-dibenzo[b,d]pyran
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical-grade intermediate adheres to stringent quality protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere or in a moisture-controlled environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.