Description

Carbamic Acid, Bromomethyl-, Ethyl Ester (9Ci) is a specialized brominated carbamate ester building block. This compound is valued for its reactive bromomethyl group, which serves as a versatile handle for further chemical modifications in synthetic organic chemistry. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring carbamate or functionalized methylene linkages.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Chemical Biology & Proteomics: Acts as a reagent for protein labeling or as a precursor to activity-based probes due to its electrophilic bromomethyl moiety.
• Polymer Modification: Employed to introduce functional groups into polymer chains for creating specialty materials with tailored properties.
• Cross-coupling Reactions: Serves as a substrate in palladium-catalyzed reactions, such as Suzuki or Heck couplings, for carbon-carbon bond formation.
• Nucleophilic Substitution: The bromine atom is readily displaced by various nucleophiles (amines, thiols, alkoxides), enabling diverse molecular diversification.

Basic Information

Product Name	Carbamic Acid, Bromomethyl-, Ethyl Ester (9Ci)
CAS No.	137731-99-8
Molecular Formula	C5H8BrNO2
Molecular Weight	194.03 g/mol
Synonyms	Ethyl N-(bromomethyl)carbamate; N-(Bromomethyl)carbamic Acid Ethyl Ester; Carbamic acid, (bromomethyl)-, ethyl ester; Bromomethylcarbamic acid ethyl ester; Ethyl bromomethylcarbamate; (Bromomethyl)carbamic acid ethyl ester; N-Carbethoxyaminomethyl bromide
EINECS	Contact for details

Quality Control

Our Carbamic Acid, Bromomethyl-, Ethyl Ester (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC/NMR), impurity profile, and physical characteristics are provided and available upon request to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.