Description

1-Iodo-2-[2-(Trimethylsilyl)ethynyl]benzene is a specialized organosilicon building block featuring both an iodoaryl and a protected terminal alkyne functional group. This compound is valued for its dual reactivity, enabling sequential cross-coupling and deprotection steps in complex molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel aromatic and heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used to create novel aromatic compounds with potential herbicidal, fungicidal, or insecticidal activity.
• Material Science: Serves as a precursor for conjugated polymers, organic semiconductors, and liquid crystals, where the alkyne group is integral to π-conjugation.
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugation linkers, leveraging the orthogonal reactivity of the iodo and alkyne groups.
• Organic Synthesis: A versatile building block for constructing complex natural products and functionalized arenes through sequential functionalization strategies.

Basic Information

Product Name	1-Iodo-2-[2-(Trimethylsilyl)ethynyl]benzene
CAS No.	137648-47-6
Molecular Formula	C11H13ISi
Molecular Weight	300.21 g/mol
Synonyms	2-(Trimethylsilyl)ethynyl-1-iodobenzene; 1-Iodo-2-[(trimethylsilyl)ethynyl]benzene; 2-Iodophenyl(trimethylsilyl)acetylene; o-Iodophenyl(trimethylsilyl)acetylene; (2-Iodophenyl)ethynyltrimethylsilane; Benzene, 1-iodo-2-[2-(trimethylsilyl)ethynyl]-; TMS-protected 2-iodophenylacetylene
EINECS	Contact for details

Quality Control

Our production of 1-Iodo-2-[2-(Trimethylsilyl)ethynyl]benzene adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by NMR (¹H, ¹³C), GC or HPLC analysis, and identity confirmation by FT-IR. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.