Description

4-(2-Amino-Thiazol-4-Yl)-1-Oxa-Spiro[4.5]Decan-2-One is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic oxa-decane scaffold fused with an amino-thiazole moiety. This compound is critical for the synthesis of novel, complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and proprietary drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules with improved efficacy and safety profiles.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of complex organic molecules for clinical trials.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry, spiro compound synthesis, and new reaction methodologies.
• Pre-clinical Development: Serves as a critical starting material for producing batches of experimental compounds required for pharmacological and toxicological testing.

Basic Information

Product Name	4-(2-Amino-Thiazol-4-Yl)-1-Oxa-Spiro[4.5]Decan-2-One
CAS No.	137180-65-5
Molecular Formula	C₁₃H₁₉N₃O₂S
Molecular Weight	281.37 g/mol
Synonyms	1-Oxa-spiro[4.5]decan-2-one, 4-(2-amino-4-thiazolyl)-; 4-(2-Aminothiazol-4-yl)-1-oxaspiro[4.5]decan-2-one; 4-(2-Amino-1,3-thiazol-4-yl)-1-oxaspiro[4.5]decan-2-one; 1-Oxaspiro[4.5]decan-2-one, 4-(2-amino-4-thiazolyl)-; CAS 137180-65-5; 4-(2-Amino-4-thiazolyl)-1-oxaspiro[4.5]decan-2-one
EINECS	Contact for details

Quality Control

Our 4-(2-Amino-Thiazol-4-Yl)-1-Oxa-Spiro[4.5]Decan-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.