Description

1-((tert-Butyldimethylsilyl)Oxy)-3-Chloropropan-2-Ol is a high-value organosilicon-protected chlorohydrin intermediate, essential for precise synthetic transformations in advanced chemical manufacturing. This compound matters because it provides a versatile handle for selective functionalization, enabling the synthesis of complex molecules with high fidelity and yield. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active pharmaceutical ingredients (APIs), chiral ligands, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Chiral Synthesis: Used in the preparation of enantiomerically pure compounds, serving as a precursor for chiral auxiliaries and ligands.
• Agrochemical Development: Intermediate in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Polymer & Material Science: Monomer or functionalization agent for creating specialty polymers, silicones, and surface-modifying materials.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group protects alcohol functionalities during complex synthetic sequences.
• Cross-Coupling & Functionalization: Serves as an electrophilic substrate in various metal-catalyzed cross-coupling reactions for carbon-carbon bond formation.

Basic Information

Product Name	1-((tert-Butyldimethylsilyl)Oxy)-3-Chloropropan-2-Ol
CAS No.	136917-95-8
Molecular Formula	C9H21ClO2Si
Molecular Weight	224.80 g/mol
Synonyms	3-Chloro-2-hydroxypropyl tert-butyldimethylsilyl ether; 2-Propanol, 1-chloro-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 1-Chloro-3-((tert-butyldimethylsilyl)oxy)propan-2-ol; TBDMS ether of 3-chloro-1,2-propanediol; (3-Chloro-2-hydroxypropoxy)(tert-butyl)dimethylsilane; tert-Butyl((3-chloro-2-hydroxypropoxy)dimethylsilane; Glycidyl tert-butyldimethylsilyl ether hydrochloride (related)
EINECS	Contact for details

Quality Control

Our 1-((tert-Butyldimethylsilyl)Oxy)-3-Chloropropan-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. We provide comprehensive analytical data, including HPLC/GC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) detailing all specifications is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.