Description

5H-Pyrrolo[3,4-B]Pyridin-5-One, 6,7-Dihydro-6-(2-Hydroxyethyl)- is a high-purity, advanced pharmaceutical intermediate with a fused heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D departments, fine chemical manufacturers, and contract research organizations (CROs) requiring reliable, high-quality intermediates for complex synthetic pathways. CAS No. 136842-80-3.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and cancer.
• Organic Synthesis Building Block: Used in research-scale and pilot-scale organic chemistry for constructing complex polycyclic molecular frameworks.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional labs for methodological development and the study of heterocyclic chemistry.
• Bioconjugation Chemistry: The hydroxyethyl side chain offers a potential handle for further functionalization and bioconjugation strategies.

Basic Information

Product Name	5H-Pyrrolo[3,4-B]Pyridin-5-One, 6,7-Dihydro-6-(2-Hydroxyethyl)-
CAS No.	136842-80-3
Molecular Formula	C9H10N2O2
Molecular Weight	178.19 g/mol
Synonyms	6-(2-Hydroxyethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one; 6-(2-Hydroxyethyl)-5H-pyrrolo[3,4-b]pyridin-5-one, 6,7-dihydro-; 136842-80-3; 6-(2-Hydroxyethyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one; Pyrrolopyridinone derivative; Fused tricyclic lactam intermediate
EINECS	Contact for details

Quality Control

Our 5H-Pyrrolo[3,4-B]Pyridin-5-One, 6,7-Dihydro-6-(2-Hydroxyethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your internal quality standards and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.