Description

Azidoiodoketanserin is a specialized, high-purity chemical building block designed for advanced pharmaceutical and biochemical research. This compound is critical for the development of novel radioligands and molecular probes targeting serotonin 5-HT2A receptors. It is primarily utilized by research scientists and process development chemists in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors for drug discovery and neuropharmacology studies.

Application

• Radioligand Synthesis: Key precursor for the development of iodine-125 (125I) labeled compounds used in receptor binding assays and autoradiography studies.
• Molecular Probe Development: Serves as a versatile intermediate for creating photoaffinity labels and activity-based probes to study 5-HT2A receptor structure and function.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to design and synthesize new analogs of ketanserin with modified pharmacological profiles.
• Bioconjugation: The azide functional group enables click chemistry applications for attaching the pharmacophore to various carriers, surfaces, or reporter molecules.
• Preclinical Neuropharmacology: Essential for producing tracers used in positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging agent development.

Basic Information

Product Name	Azidoiodoketanserin
CAS No.	136769-36-3
Molecular Formula	C22H22IN7O2
Molecular Weight	567.36 g/mol
Synonyms	1-[4-(4-Azido-2-iodobenzoyl)piperazin-1-yl]-2-(4-fluorophenyl)ethan-1-one; 4-Azido-2-iodo-1-[4-[2-(4-fluorophenyl)acetyl]piperazin-1-yl]methanone; Azidoiodoketanserin; N3-Iodoketanserin azide; Ketanserin azidoiodo derivative; 5-HT2A receptor probe precursor
EINECS	Contact for details

Quality Control

Every batch of Azidoiodoketanserin is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from HPLC, NMR, and mass spectrometry analyses. Our quality commitment supports compliance with cGMP guidelines for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C under an inert atmosphere such as argon or nitrogen. The container should be kept in a cool, dry, and well-ventilated area, away from heat and incompatible materials. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.