Description

3-Hydroxy Pravastatin is a key pharmaceutical intermediate and metabolite of the cholesterol-lowering drug Pravastatin. This compound matters for its critical role in the research, development, and quality control of statin-based therapeutics, ensuring drug efficacy and safety. It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in metabolic studies, impurity profiling, and the synthesis of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Pravastatin and related statin compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical labs.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the drug's metabolism and activity.
• Impurity Profiling: Serves as a known impurity or degradation product standard to monitor and control the quality of Pravastatin API.
• Biochemical Research: Used in studies investigating the mechanism of action of HMG-CoA reductase inhibitors.
• Custom Synthesis: A starting material for the preparation of novel statin analogs and derivatives in medicinal chemistry.

Basic Information

Product Name	3-Hydroxy Pravastatin
CAS No.	136657-41-5
Molecular Formula	C₂₃H₃₆O₈
Molecular Weight	440.53 g/mol
Synonyms	Pravastatin 3-Hydroxy Derivative; Pravastatin 3-Hydroxy Analog; 3-Hydroxy Pravastatin Sodium Salt (common form); (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-Hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid; Pravastatin 3-OH; Pravastatin Hydroxy Metabolite
EINECS	Contact for details

Quality Control

Our 3-Hydroxy Pravastatin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.