Description

Fmoc-D-Trp-Opfp CAS NO 136554-94-4 is a specialized, activated ester derivative of the unnatural D-configured amino acid tryptophan, protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and racemization-free incorporation of D-tryptophan into complex peptide sequences. It is essential for research and production in pharmaceutical development, particularly for creating peptide-based therapeutics, antimicrobial agents, and biochemical probes. The high reactivity of the pentafluorophenyl (OPfp) ester group ensures excellent coupling efficiency under mild conditions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the automated, stepwise synthesis of peptides containing D-tryptophan residues.
• Pharmaceutical Research & Development: Used in the discovery and production of novel peptide drugs, hormones, and antimicrobial peptides where D-amino acids enhance stability and bioactivity.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides and proteins for diagnostic and therapeutic applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new biologically active compounds.
• Academic & Institutional Research: A fundamental tool for studying peptide structure, function, and interactions in biochemistry and molecular biology labs.
• Production of Non-Natural Peptides: Enables the synthesis of peptides with tailored properties for material science and bioengineering.

Basic Information

Product Name	Fmoc-D-Trp-Opfp
CAS No.	136554-94-4
Molecular Formula	C33H23F5N2O5
Molecular Weight	622.55 g/mol
Synonyms	Fmoc-D-tryptophan pentafluorophenyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-tryptophan 2,3,4,5,6-pentafluorophenyl ester; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-indol-3-yl)propanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-D-Trp-OPfp; Fmoc-D-Trp-OPh(2,3,4,5,6-F5); Nα-Fmoc-D-tryptophan pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-Trp-Opfp is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive applications like pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of global research and development customers.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.