Description

Methyl 2-(Trifluoromethyl)Nicotinate CAS NO 136483-17-5 is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique combination of the electron-withdrawing trifluoromethyl group and the versatile methyl ester functionality, enabling precise molecular modifications. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve metabolic stability and bioavailability.
• Material Science Precursor: Used in the synthesis of specialty chemicals, liquid crystals, and advanced polymers requiring fluorinated aromatic components.
• Research & Development: A versatile reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing tailored compounds for client projects.

Basic Information

Product Name	Methyl 2-(Trifluoromethyl)Nicotinate
CAS No.	136483-17-5
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	Methyl 2-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-(trifluoromethyl)-, methyl ester; 2-(Trifluoromethyl)nicotinic acid methyl ester; Methyl 2-trifluoromethylnicotinate; Nicotinic acid, 2-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2-(Trifluoromethyl)Nicotinate adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we support compliance with relevant regulatory frameworks including REACH and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.