Description

1'-Methyl-5-Methoxyspiro[Indoline-3,3'-Pyrrolidine]-2-One is a complex spirocyclic organic compound featuring a fused indoline-pyrrolidine structure. This compound serves as a versatile and high-value synthetic intermediate in advanced organic synthesis, particularly for constructing pharmacologically active molecules. It is primarily needed by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization.
• Alkaloid Synthesis: Serves as a precursor for the construction of complex spirocyclic and polycyclic alkaloid analogs.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein interactions.
• Advanced Material Science: Potential monomer or precursor for specialty polymers and organic electronic materials due to its rigid, conjugated structure.

Basic Information

Item	Details
Product Name	1'-Methyl-5-Methoxyspiro[Indoline-3,3'-Pyrrolidine]-2-One
CAS No.	136247-72-8
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	1'-Methyl-5-methoxyspiro[indoline-3,3'-pyrrolidin]-2-one; 5-Methoxy-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one; Spiro[indoline-3,3'-pyrrolidine]-2-one, 1'-methyl-5-methoxy-; 136247-72-8; 1'-Methyl-5-methoxyspiro[indole-3,3'-pyrrolidine]-2-one; 5-Methoxy-1'-methyl-2,3-dihydrospiro[indole-3,3'-pyrrolidin]-2-one
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS), to ensure it meets stringent customer specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.