Description

Ethanone, 1-[3-(Trimethylsilyl)Oxiranyl]-, (2S-Trans)- (9Ci) is a high-value, chiral organosilicon building block featuring a reactive oxirane (epoxide) ring. This compound matters for its role in stereoselective synthesis, enabling the controlled introduction of functionalized, silicon-containing moieties into complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and advanced materials sectors for creating novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Used in stereocontrolled ring-opening reactions to produce enantiomerically pure alcohols, amines, and other functional groups.
• Organosilicon Chemistry: Serves as a precursor for introducing the trimethylsilyl group into target molecules, modifying their lipophilicity and metabolic stability.
• Advanced Material Research: Employed in the development of specialty silicones, silsesquioxanes, and other hybrid organic-inorganic polymers with tailored properties.
• Agrochemical Synthesis: Utilized in the research and development of new, more effective chiral active ingredients for crop protection.
• Ligand and Catalyst Development: Acts as a building block for creating novel chiral ligands and organocatalysts used in enantioselective transformations.

Basic Information

Product Name	Ethanone, 1-[3-(Trimethylsilyl)Oxiranyl]-, (2S-Trans)- (9Ci)
CAS No.	136158-37-7
Molecular Formula	C8H16O2Si
Molecular Weight	172.30 g/mol
Synonyms	(2S,3S)-1-(Oxiran-2-yl)-3-(trimethylsilyl)propan-1-one; (2S,3S)-3-(Trimethylsilyl)oxiran-2-yl methyl ketone; 1-[(2S,3S)-3-(Trimethylsilyl)oxiran-2-yl]ethanone; (2S-trans)-1-[3-(Trimethylsilyl)oxiranyl]ethanone; trans-1-(3-Trimethylsilyloxiranyl)ethanone; Chiral Trimethylsilyl Epoxide Ketone; TMS Epoxide Ketone Intermediate
EINECS	Contact for details

Quality Control

Our Ethanone, 1-[3-(Trimethylsilyl)Oxiranyl]-, (2S-Trans)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.