Description

Spiro[Indene-2,4'-Piperidin]-1(3H)-One CAS NO 136080-25-6 is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant commercial importance as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical suppliers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates targeting neurological disorders.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing complex spirocyclic scaffolds, enabling structure-activity relationship (SAR) studies.
• CNS Drug Development: Serves as a core structure in the synthesis of potential therapeutics for conditions such as depression, anxiety, and schizophrenia.
• Oncological Research: Employed in the development of small-molecule inhibitors and targeted cancer therapies.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Academic & Industrial R&D: Used in research institutions and corporate labs for exploratory chemistry and new molecular entity (NME) discovery.

Basic Information

Product Name	Spiro[Indene-2,4'-Piperidin]-1(3H)-One
CAS No.	136080-25-6
Molecular Formula	C14H15NO
Molecular Weight	213.28 g/mol
Synonyms	1'H-Spiro[indene-2,4'-piperidin]-1-one; Spiro(indene-2,4'-piperidin)-1-one; 1,3-Dihydrospiro[indene-2,4'-piperidin]-1-one; 136080-25-6; Spiro[indene-2,4'-piperidine]-1(3H)-one; 1'H-Spiro[indene-2,4'-piperidine]-1-one; 1,3-Dihydro-2H-spiro[indene-2,4'-piperidin]-1-one
EINECS	Contact for details

Quality Control

Our Spiro[Indene-2,4'-Piperidin]-1(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.