Description

Dalvastatin CAS NO 135910-20-2 is a synthetic, small-molecule compound belonging to the statin class, primarily recognized for its role as a potent and selective inhibitor of HMG-CoA reductase, a key enzyme in the cholesterol biosynthesis pathway. This targeted mechanism makes it a critical intermediate in pharmaceutical research and development for cardiovascular therapeutics. It is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on developing novel lipid-lowering agents and studying cholesterol metabolism.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of advanced statin-based active pharmaceutical ingredients (APIs) for cholesterol management.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic assays to study HMG-CoA reductase inhibition kinetics and mechanism of action.
• Drug Discovery & Development: Serves as a lead compound or structural template for medicinal chemistry programs aimed at creating new cardiovascular drugs with improved efficacy and safety profiles.
• Academic Research: Employed in university and institutional labs for investigating lipid metabolism, atherosclerosis models, and the pharmacodynamics of cholesterol synthesis inhibitors.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of scalable synthetic routes for the commercial production of statin medications.

Basic Information

Product Name	Dalvastatin
CAS No.	135910-20-2
Molecular Formula	C23H34N2O5
Molecular Weight	418.53 g/mol
Synonyms	Dalvastatin; (3R,5S)-7-[4-(4-Fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid; BMS 180431; S-2468; SQ 33600; SQ-33600; SQ33600; (E)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid (common IUPAC); HMG-CoA reductase inhibitor BMS-180431.
EINECS	Contact for details

Quality Control

Our Dalvastatin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Specifications typically align with in-house pharmacopeial standards for identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.