Description

1-Benzyl-2-Methyl-Indoline-1,2-Dicarboxylate (Methyl-1-Cbz-2-Indoline-Carboxylate) is a high-purity, protected indoline derivative serving as a critical chiral building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals. It is essential for research and production in pharmaceutical, agrochemical, and specialty chemical industries where precise stereochemistry and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Research: Used to construct constrained, non-natural amino acid analogs and peptide backbone modifications.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for developing novel chiral ligands and organocatalysts.
• Agrochemical Synthesis: Intermediate in the production of advanced, stereochemically defined crop protection agents.
• Academic & R&D Laboratories: Employed in methodological development for new synthetic routes and heterocyclic chemistry studies.
• Fine Chemical Production: Building block for high-value specialty chemicals, including dyes, pigments, and advanced materials.

Basic Information

Product Name	1-Benzyl-2-Methyl-Indoline-1,2-Dicarboxylate (Methyl-1-Cbz-2-Indoline-Carboxylate)
CAS No.	135829-03-7
Molecular Formula	C19H17NO4
Molecular Weight	323.34 g/mol
Synonyms	Methyl 1-[(benzyloxy)carbonyl]-2-methyl-2,3-dihydro-1H-indole-2-carboxylate; 1-Cbz-2-methylindoline-2-carboxylic acid methyl ester; Methyl 1-Cbz-2-indolinecarboxylate; 1-(Benzyloxycarbonyl)-2-methylindoline-2-carboxylic Acid Methyl Ester; 2,3-Dihydro-1H-indole-2-carboxylic acid, 1-[(phenylmethoxy)carbonyl]-2-methyl-, methyl ester; Methyl 1-(benzyloxycarbonyl)-2-methylindoline-2-carboxylate; 1-Cbz-2-methyl-2,3-dihydro-1H-indole-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 1-Benzyl-2-Methyl-Indoline-1,2-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure compliance with high-purity standards suitable for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.