Description

Methyl n-Cbz-Morpholine-2-Carboxylate is a high-purity, protected amino acid derivative widely used as a critical building block in advanced organic synthesis. This compound is essential for the controlled introduction of the morpholine-2-carboxylic acid moiety into complex molecular architectures, offering significant value in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical companies engaged in peptide mimetics, medicinal chemistry, and the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and antiviral targets.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate constrained, morpholine-based amino acid analogs, enhancing peptide stability and bioactivity.
• Medicinal Chemistry & SAR Studies: Serves as a versatile scaffold for structure-activity relationship (SAR) explorations to optimize drug potency, selectivity, and pharmacokinetic properties.
• Protecting Group Strategy: The Cbz (carboxybenzyl) protecting group allows for orthogonal deprotection strategies in multi-step synthetic sequences, crucial for complex molecule assembly.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for investigating biological pathways and target engagement.

Basic Information

Product Name	Methyl n-Cbz-Morpholine-2-Carboxylate
CAS No.	135782-22-8
Molecular Formula	C14H17NO5
Molecular Weight	279.29 g/mol
Synonyms	Methyl N-[(benzyloxy)carbonyl]morpholine-2-carboxylate; Methyl (2S)-4-[(benzyloxy)carbonyl]morpholine-2-carboxylate; (S)-Methyl 4-((benzyloxy)carbonyl)morpholine-2-carboxylate; N-Cbz-Morpholine-2-carboxylic Acid Methyl Ester; CBZ-Morpholine-2-Carboxylic Acid Methyl Ester; (S)-Methyl 4-(Cbz)morpholine-2-carboxylate; Methyl 4-(benzyloxycarbonyl)morpholine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl n-Cbz-Morpholine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification and impurity profiling. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.