Description

(S)-1-Phenyl-n-((Trimethylsilyl)Methyl)Ethanamine CAS NO 135782-16-0 is a chiral amine intermediate featuring a phenyl group and a trimethylsilylmethyl substituent, which imparts unique steric and electronic properties. This compound is valued for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing active pharmaceutical ingredients (APIs) and functional ligands.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Catalyst Ligand Precursor: Used to develop chiral ligands for transition metal catalysis, enabling enantioselective synthesis.
• Agrochemical Synthesis: Serves as an intermediate in the production of chiral pesticides and herbicides.
• Organic Synthesis Reagent: Employed in nucleophilic addition and alkylation reactions to introduce the (trimethylsilyl)methylamine moiety.
• Material Science Research: Investigated as a monomer or functional additive in the development of specialty polymers and silicones.

Basic Information

Product Name	(S)-1-Phenyl-n-((Trimethylsilyl)Methyl)Ethanamine
CAS No.	135782-16-0
Molecular Formula	C₁₂H₂₁NSi
Molecular Weight	207.39 g/mol
Synonyms	(S)-1-Phenyl-N-((trimethylsilyl)methyl)ethanamine; (S)-α-Methylbenzyl(trimethylsilylmethyl)amine; (S)-N-[(Trimethylsilyl)methyl]-1-phenylethanamine; (S)-1-Phenylethyl(trimethylsilylmethyl)amine; (S)-N-((Trimethylsilyl)methyl)-α-methylbenzylamine; (S)-N-(Trimethylsilylmethyl)-1-phenylethylamine; (S)-TMSM-PEA; (S)-Trimethylsilylmethyl-α-methylbenzylamine
EINECS	Contact for details

Quality Control

Our (S)-1-Phenyl-n-((Trimethylsilyl)Methyl)Ethanamine is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.