Description

tert-Butyl 4-(2-Ethoxy-2-Oxoethylidene)Piperidine-1-Carboxylate CAS NO 135716-08-4 is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with a protected amine and an ethoxy-oxoethylidene functional group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and metabolic disorder therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in process chemistry, medicinal chemistry, and the scale-up of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in the discovery and optimization phase for creating new chemical entities (NCEs) with potential therapeutic activity.
• Process Development & Scale-Up: Serves as a critical raw material for process chemists during route scouting and optimization for commercial API manufacturing.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	tert-Butyl 4-(2-Ethoxy-2-Oxoethylidene)Piperidine-1-Carboxylate
CAS No.	135716-08-4
Molecular Formula	C15H25NO4
Molecular Weight	283.36 g/mol
Synonyms	1-Boc-4-(2-ethoxy-2-oxoethylidene)piperidine; 1-(tert-Butoxycarbonyl)-4-(2-ethoxy-2-oxoethylidene)piperidine; 4-(2-Ethoxy-2-oxoethylidene)-1-piperidinecarboxylic acid tert-butyl ester; 4-(Ethoxycarbonylmethylene)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(ethoxycarbonylmethylene)piperidine-1-carboxylate; 1-Boc-4-(ethoxycarbonylmethylene)piperidine; 135716-08-4; 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Ethoxy-2-Oxoethylidene)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material is suitable for use in advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.