Description

Mpegn-Sc 2K, 5K, 10K, 20K is a high-purity, monomethoxy poly(ethylene glycol) succinimidyl carboxymethyl ester, a functionalized PEG derivative widely used as a linker in bioconjugation. This product is critical for creating stable, non-immunogenic conjugates in therapeutic and diagnostic applications. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent industries who require reliable, well-characterized PEGylation reagents. The compound is identified by CAS No. 135649-01-3.

Application

• Biopharmaceutical PEGylation: Conjugation to proteins, peptides, and antibodies to enhance solubility, reduce immunogenicity, and prolong circulation half-life.
• Drug Delivery Systems: Functionalization of liposomes, nanoparticles, and polymeric micelles for targeted drug delivery.
• Diagnostic Reagents: Labeling of antibodies, enzymes, and other biomolecules for immunoassays and biosensors.
• Biomaterial Modification: Surface functionalization of medical devices and implants to improve biocompatibility and reduce fouling.
• Cross-linking Agent: Used in the synthesis of hydrogels and polymer networks for controlled release applications.
• Research & Development: A key reagent in academic and industrial R&D for exploring novel bioconjugates and therapeutic modalities.

Basic Information

Product Name	Mpegn-Sc 2K, 5K, 10K, 20K
CAS No.	135649-01-3
Molecular Formula	CnH2n+2On+1 • C6H5NO4 (Variable based on PEG chain length 'n')
Molecular Weight	~2,000 Da (2K), ~5,000 Da (5K), ~10,000 Da (10K), ~20,000 Da (20K)
Synonyms	mPEG-SCM; Methoxy PEG Succinimidyl Carboxymethyl Ester; mPEG-Succinimidyl Carboxymethyl; α-Methoxy-ω-succinimidyl carboxymethyl poly(ethylene glycol); SC-PEG; PEG-SCM; NHS-PEG; Poly(ethylene glycol) methyl ether carboxymethyl N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Mpegn-Sc grades are manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR for structural confirmation, HPLC/GPC for purity and molecular weight distribution analysis, and end-group titration to quantify active ester content. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to ensure compliance with your research and cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and hydrolysis of the active ester. For long-term stability, store under inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (NMR)	Conforms to structure
Molecular Weight (GPC)	Nominal MW ± 10% (2K, 5K, 10K, 20K)
Purity (HPLC)	≥ 95%
Polydispersity Index (PDI)	≤ 1.05
Functional Substitution	≥ 90%
Moisture Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.