Description

(S)-2-((tert-Butyldimethylsilyl)Oxy)Propan-1-Ol is a chiral, protected alcohol intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a versatile building block for constructing complex molecules with defined stereochemistry, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, enantiomerically pure intermediates for the synthesis of active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of enantiomerically pure drugs, particularly those targeting central nervous system (CNS) disorders, antivirals, and anti-inflammatory agents.
• Asymmetric Synthesis: Used as a starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric excess.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products where the (S)-configured propyl alcohol moiety is required.
• Agrochemical Development: Serves as a precursor in the creation of chiral pesticides and herbicides, where biological activity is often stereospecific.
• Ligand and Catalyst Preparation: Utilized for the synthesis of chiral ligands and organocatalysts used in enantioselective transformations.
• Peptidomimetics and Prodrugs: Incorporated into the backbone of peptide analogs and prodrug molecules to modulate bioavailability and metabolic stability.

Basic Information

Product Name	(S)-2-((tert-Butyldimethylsilyl)Oxy)Propan-1-Ol
CAS No.	135614-57-2
Molecular Formula	C9H22O2Si
Molecular Weight	190.36 g/mol
Synonyms	(S)-1-(tert-Butyldimethylsilyloxy)-2-propanol; (S)-2-(tert-Butyldimethylsiloxy)-1-propanol; (S)-1-Hydroxy-2-[(tert-butyldimethylsilyl)oxy]propane; (S)-2-(TBDMSO)propan-1-ol; (S)-TBDMS-protected 1,2-propanediol; (S)-1,2-Propanediol, 1-(1,1-dimethylethyl)dimethylsilyl ether; (S)-1,2-Propanediol, 1-[(1,1-dimethylethyl)dimethylsilyl] ether
EINECS	Contact for details

Quality Control

Our (S)-2-((tert-Butyldimethylsilyl)Oxy)Propan-1-Ol is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC/GC), and identity confirmation. Our quality commitment aligns with the standards required for cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.