Description

(4S,5R)-4β,10β-Dihydroxy-3-Methylene-6β-[(E)-1-Propenyl]-2-Oxaspiro[4.5]Dec-7-Ene-1,9-Dione is a high-purity, stereochemically defined spirocyclic compound with significant synthetic utility. This advanced intermediate is valued for its complex molecular architecture, which serves as a critical building block in the synthesis of biologically active molecules. It is primarily sought after by research institutions and pharmaceutical development teams working on novel therapeutic agents, natural product synthesis, and complex organic transformations.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Natural Product Synthesis: Used in the total or semi-synthesis of complex natural products with spirocyclic or terpenoid backbones.
• Medicinal Chemistry Research: Serves as a scaffold for constructing compound libraries in drug discovery programs targeting various disease pathways.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce multiple chiral centers in target molecules.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and biological mechanisms.
• Process Chemistry Development: Acts as a benchmark or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	(4S,5R)-4β,10β-Dihydroxy-3-Methylene-6β-[(E)-1-Propenyl]-2-Oxaspiro[4.5]Dec-7-Ene-1,9-Dione
CAS No.	135048-14-5
Molecular Formula	C14H16O5
Molecular Weight	264.27 g/mol
Synonyms	4β,10β-Dihydroxy-3-methylene-6β-[(1E)-1-propen-1-yl]-2-oxaspiro[4.5]dec-7-ene-1,9-dione; (4S,5R)-4,10-Dihydroxy-3-methylene-6-[(E)-1-propenyl]-2-oxaspiro[4.5]dec-7-ene-1,9-dione; Spirocyclic sesquiterpene derivative; 2-Oxaspiro[4.5]dec-7-ene-1,9-dione, 4,10-dihydroxy-3-methylene-6-[(1E)-1-propen-1-yl]-, (4S,5R)-; 135048-14-5; (4S,5R)-4,10-Dihydroxy-3-methylene-6-(E-propenyl)-2-oxaspiro[4.5]dec-7-ene-1,9-dione
EINECS	Contact for details

Quality Control

Our (4S,5R)-4β,10β-Dihydroxy-3-Methylene-6β-[(E)-1-Propenyl]-2-Oxaspiro[4.5]Dec-7-Ene-1,9-Dione is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. All materials are subjected to comprehensive analytical testing, including HPLC, NMR, and chiral analysis, to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support development projects requiring material produced under GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.