Description

8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester is a high-value spirocyclic building block and protected keto-acid derivative essential for advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the production of complex pharmaceuticals and fine chemicals, enabling precise molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its spirocyclic structure contributes to biological activity.
• Fine Chemical Production: Serves as a versatile building block for creating complex flavors, fragrances, and other high-value specialty chemicals.
• Academic & Industrial R&D: Employed in methodological studies and process chemistry for developing new asymmetric synthesis routes and catalytic transformations.
• Material Science Precursor: Potential use in the synthesis of specialized polymers and ligands with specific stereochemical properties.

Basic Information

Product Name	8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester
CAS No.	134970-49-3
Molecular Formula	C11H18O5
Molecular Weight	230.26 g/mol
Synonyms	Ethyl 8-hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylate; 8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic Acid Ethyl Ester; 8-Ethoxycarbonyl-8-hydroxy-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-hydroxy-, ethyl ester; Spirocyclic keto-acid ethyl ester; Protected cyclohexanone derivative
EINECS	Contact for details

Quality Control

Our 8-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboxylic acid ethyl ester is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from strong bases and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.