Description

(1S,3S)-1-Ethyl-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylic Acid is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and psychiatric conditions. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for its precise stereochemistry, which is critical for ensuring the efficacy and safety of final drug products.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug candidates, particularly in central nervous system (CNS) targeted therapies.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production route for specific tetrahydro-β-carboline alkaloid derivatives with potential therapeutic activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities.
• Process Chemistry Development: Employed in route scouting and optimization for scalable GMP manufacturing of advanced intermediates.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Investigated for its interaction with specific biological receptors and enzymes due to its core β-carboline structure.

Basic Information

Product Name	(1S,3S)-1-Ethyl-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylic Acid
CAS No.	134930-19-1
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	(1S,3S)-1-Ethyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid; (3S,13bS)-3-Ethyl-2,3,4,13b-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[2,3-b]pyridine-3-carboxylic acid; 1-Ethyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, (1S,3S)-; Tetrahydro-β-carboline-3-carboxylic acid derivative; 1-Ethyl-THβC-3-COOH; (S,S)-1-Ethyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our (1S,3S)-1-Ethyl-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S,S isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.