Description

3,4-o-Benzylidene-D-Ribo-1,5-Lactone is a high-purity, protected sugar lactone derivative that serves as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the stereoselective construction of complex molecules, particularly nucleoside analogs and other biologically active compounds. This intermediate is essential for research and development laboratories in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new active ingredients with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Fine Chemical Synthesis: Used as a versatile building block for constructing complex carbohydrates, natural products, and other stereochemically defined molecules.
• Agrochemical Research: Employed in the development of chiral active ingredients for crop protection agents.
• Academic & R&D: A valuable tool in organic chemistry research for methodology development and exploring new synthetic pathways.
• Glycochemistry: Serves as a protected intermediate for the preparation of more complex sugar derivatives and glycoconjugates.

Basic Information

Product Name	3,4-o-Benzylidene-D-Ribo-1,5-Lactone
CAS No.	134877-40-0
Molecular Formula	C12H12O5
Molecular Weight	236.22 g/mol
Synonyms	D-Ribo-1,5-lactone 3,4-O-benzylidene acetal; 3,4-O-Benzylidene-D-ribono-1,5-lactone; 3,4-O-(Phenylmethylene)-D-ribono-1,5-lactone; Benzylidene-D-ribonolactone; (3aR,6R,6aR)-6-(Phenylmethoxy)tetrahydrofuro[3,4-d][1,3]dioxol-4(6aH)-one
EINECS	Contact for details

Quality Control

Our 3,4-o-Benzylidene-D-Ribo-1,5-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	Contact for details
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.