Description

Meta-Chlorambucil CAS NO 134862-11-6 is a chlorinated nitrogen mustard derivative and a structural analog of the chemotherapeutic agent chlorambucil. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a key intermediate or a novel active pharmaceutical ingredient (API) in oncology. It is primarily utilized by research institutions, pharmaceutical manufacturers, and fine chemical suppliers engaged in the synthesis of targeted cancer therapies and the exploration of new alkylating agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nitrogen mustard-based chemotherapeutic agents and targeted cancer drugs.
• Oncology Research: Used as a reference standard or experimental compound in biochemical and pharmacological studies to investigate mechanisms of alkylation, DNA cross-linking, and apoptosis induction.
• API Development: Employed in the research and development of new Active Pharmaceutical Ingredients (APIs) for the treatment of lymphomas, leukemias, and other malignancies.
• Bioconjugation Studies: Acts as a candidate molecule for creating antibody-drug conjugates (ADCs) or other targeted delivery systems in cancer therapy.
• Preclinical Testing: Utilized in *in vitro* and *in vivo* studies to evaluate efficacy, toxicity, and pharmacokinetic profiles of new therapeutic candidates.
• Process Chemistry: Applied in route scouting and optimization for the scalable synthesis of complex pharmaceutical molecules.

Basic Information

Product Name	Meta-Chlorambucil
CAS No.	134862-11-6
Molecular Formula	C14H19Cl2NO2
Molecular Weight	304.21 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]-2-chlorobenzoic Acid; 2-Chloro-4-[bis(2-chloroethyl)amino]benzoic Acid; m-Chlorambucil; NSC 75766; Chlorambucil Impurity; Benzoic acid, 4-[bis(2-chloroethyl)amino]-2-chloro-
EINECS	Contact for details

Quality Control

Our Meta-Chlorambucil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.