Description

(4-Iodophenylethynyl)Trimethylsilane CAS NO 134856-58-9 is a high-value organosilicon intermediate featuring a terminal alkyne protected by a trimethylsilyl (TMS) group and an iodine substituent on the aromatic ring. This unique structure makes it a versatile and critical building block for advanced organic synthesis, particularly in cross-coupling reactions and material science. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in Sonogashira and other palladium-catalyzed cross-coupling reactions for synthesizing novel drug candidates and bioactive molecules.
• Agrochemical Synthesis: Used to create advanced active ingredients and fine chemicals with specific structural motifs for crop protection.
• Material Science Research: Serves as a monomer or building block for developing organic electronic materials, such as conductive polymers and liquid crystals.
• Chemical Biology Probes: Employed in click chemistry and bioconjugation strategies to label biomolecules or create molecular probes.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new synthetic pathways in organic chemistry laboratories.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and coordination chemistry.

Basic Information

Product Name	(4-Iodophenylethynyl)Trimethylsilane
CAS No.	134856-58-9
Molecular Formula	C11H13ISi
Molecular Weight	300.21 g/mol
Synonyms	1-Iodo-4-[(trimethylsilyl)ethynyl]benzene; 4-(Trimethylsilylethynyl)iodobenzene; p-Iodophenyl(trimethylsilyl)acetylene; Trimethyl((4-iodophenyl)ethynyl)silane; TMS-protected 4-iodophenylacetylene; 4-Ethynyl-1-iodobenzene trimethylsilyl derivative
EINECS	Contact for details

Quality Control

Our (4-Iodophenylethynyl)Trimethylsilane is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and structural identity. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our commitment to consistent quality and traceability supports critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.