Description

(S)-2-(((tert-Butyldimethylsilyl)Oxy)Methyl)Pyrrolidine is a high-value chiral building block and organosilicon reagent, essential for the stereoselective synthesis of complex molecules. Its core value lies in providing a protected hydroxymethyl pyrrolidine scaffold, enabling precise control over molecular architecture in advanced chemical processes. This compound is critically needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in asymmetric synthesis, particularly in the development of active pharmaceutical ingredients (APIs) and novel agrochemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of pyrrolidine-based drug candidates, including protease inhibitors and neurological agents.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Natural Product Synthesis: Building block for constructing complex natural products containing pyrrolidine or prolinol motifs.
• Agrochemical Research: Intermediate in the development of novel, stereochemically defined pesticides and herbicides.
• Material Science: Potential precursor for functionalized polymers or silicon-containing advanced materials.
• Academic & Process Chemistry: Valuable reagent for methodological development and scale-up studies in organic synthesis.

Basic Information

Product Name	(S)-2-(((tert-Butyldimethylsilyl)Oxy)Methyl)Pyrrolidine
CAS No.	134756-75-5
Molecular Formula	C11H25NOSi
Molecular Weight	215.41 g/mol
Synonyms	(S)-(-)-2-((tert-Butyldimethylsilyloxy)methyl)pyrrolidine; (S)-2-((tert-Butyldimethylsiloxy)methyl)pyrrolidine; (S)-N-Boc-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidine (protected form); (S)-Pyrrolidin-2-ylmethanol, O-(1,1-dimethylethyl)dimethylsilyl ether; (S)-TBDMS-protected prolinol; (S)-2-(Hydroxymethyl)pyrrolidine TBDMS ether; TBDMS-(S)-Prolinol; (S)-α-(Tert-butyldimethylsilyloxymethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity chiral intermediates. We employ advanced analytical techniques including chiral HPLC, GC, and NMR to guarantee enantiomeric excess and chemical purity. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.