Description

Methyl (3S)-3-Amino-3-(4-Hydroxyphenyl)Propanoate Hydrochloride is a high-purity chiral building block of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs). This compound is essential for research and production teams in the pharmaceutical and fine chemical industries, particularly those focused on neurology, endocrinology, and other therapeutic areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel APIs, especially in central nervous system (CNS) and hormonal therapies.
• Peptidomimetics Research: Used in the design and development of peptide analogs and mimetics due to its amino acid ester backbone.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Medicinal Chemistry R&D: Employed in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical manufacturing.
• Bioconjugation Chemistry: The reactive amine and ester functional groups make it suitable for linker chemistry in antibody-drug conjugates (ADCs) or prodrug development.

Basic Information

Product Name	Methyl (3S)-3-Amino-3-(4-Hydroxyphenyl)Propanoate Hydrochloride
CAS No.	134430-96-9
Molecular Formula	C10H14ClNO3
Molecular Weight	231.68 g/mol
Synonyms	(S)-Methyl 3-Amino-3-(4-hydroxyphenyl)propanoate hydrochloride; (3S)-3-Amino-3-(4-hydroxyphenyl)propanoic acid methyl ester hydrochloride; L-DOPS Methyl Ester Hydrochloride; (S)-3-Amino-3-(4-hydroxy-phenyl)-propionic acid methyl ester HCl; Methyl (S)-3-amino-3-(4-hydroxyphenyl)propionate HCl; Methyl ester of (S)-3-Amino-3-(4-hydroxyphenyl)propionic acid hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl (3S)-3-Amino-3-(4-Hydroxyphenyl)Propanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.