Description

n-Butyl-2-(5-(4-(3,17-Dihydroxyestra-1,3,5(10)-Trien-11-Yl)Phenoxy)Pentylthio)-n-Methylacetamide is a high-purity, synthetic steroid derivative with a complex molecular architecture designed for advanced research and development. This compound matters for its potential as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutic agents, particularly in endocrinology and oncology. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers require this material for synthesizing next-generation steroid-based drugs and conducting critical preclinical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Biomedical Research: Used as a reference standard or probe compound in biochemical assays to study steroid receptor interactions and signaling pathways.
• Drug Discovery & Development: Employed in preclinical research for the development of new therapeutic agents targeting hormonal disorders or cancers.
• Academic Research: Utilized in university and institutional laboratories for fundamental studies in organic chemistry, medicinal chemistry, and pharmacology.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in analytical laboratories.

Basic Information

Item	Details
Product Name	n-Butyl-2-(5-(4-(3,17-Dihydroxyestra-1,3,5(10)-Trien-11-Yl)Phenoxy)Pentylthio)-n-Methylacetamide
CAS No.	134413-34-6
Molecular Formula	C36H51NO4S
Molecular Weight	593.86 g/mol
Synonyms	11β-[4-[5-[(2-Butyl-2-methylamino-2-oxoethyl)thio]pentyloxy]phenyl]estra-1,3,5(10)-triene-3,17-diol; ICI 182,780 Impurity; Fulvestrant Related Compound; (11β)-11-[4-[5-[(2-Butyl-2-methylamino-2-oxoethyl)thio]pentoxy]phenyl]estra-1,3,5(10)-triene-3,17-diol; ZD9238 Related Substance; Steroidal Sulfur-containing Acetamide Derivative; FASLODEX Impurity
EINECS	Contact for details

Quality Control

Our n-Butyl-2-(5-(4-(3,17-Dihydroxyestra-1,3,5(10)-Trien-11-Yl)Phenoxy)Pentylthio)-n-Methylacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We can supply material compliant with research-grade specifications and support development toward cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Unknown Impurity	≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.