Description

Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1S- is a high-purity, chiral cyclobutane derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique, strained four-membered ring structure provides a valuable scaffold for constructing complex molecules with specific stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and explore new chemical spaces.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclobutane ring can contribute to unique biological activity and environmental stability.
• Material Science Research: Acts as a monomer or precursor for developing specialized polymers and liquid crystals with tailored thermal and optical properties.
• Asymmetric Catalysis: Employed as a ligand precursor or a test substrate in the development of new catalytic systems for stereoselective synthesis.
• Fragrance & Flavor Chemistry: Serves as a starting material for synthesizing complex aroma chemicals with unique olfactory profiles due to its constrained cyclic structure.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic synthesis, particularly in ring-opening and functionalization reactions of strained systems.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1S-
CAS No.	134235-09-9
Molecular Formula	C9H14O2
Molecular Weight	154.21 g/mol
Synonyms	(1S)-3-Ethylidene-2-methylcyclobutanecarboxylic acid methyl ester; Methyl (1S)-3-ethylidene-2-methylcyclobutanecarboxylate; [1S-(3E)]-3-Ethylidene-2-methylcyclobutanecarboxylic Acid Methyl Ester; (1S,2S)-3-Ethylidene-2-methylcyclobutanecarboxylic acid methyl ester; 3-Ethylidene-2-methyl-cyclobutanecarboxylic acid methyl ester, (1S)-; Chiral Cyclobutane Ester; Methyl 3-ethylidene-2-methyl-1-cyclobutanecarboxylate
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1S- adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. We employ advanced analytical techniques including chiral HPLC, GC-MS, and NMR spectroscopy to verify identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all critical parameters are provided with every shipment. Our quality management system is designed to support cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.