Description

Phthalamide-Peg3-Azide is a specialized bifunctional linker molecule designed for advanced bioconjugation and chemical synthesis. This compound is critical for creating stable, site-specific conjugates in applications ranging from drug development to materials science. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries who require high-purity, functionalized building blocks for click chemistry and PEGylation strategies.

Application

• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies via its azide functionality and amide coupling site.
• PEGylation Reagent: Used to introduce a hydrophilic polyethylene glycol (PEG) spacer to peptides, proteins, or small molecules, improving solubility and pharmacokinetic properties.
• Click Chemistry: The terminal azide group enables efficient, copper-catalyzed or strain-promoted cycloaddition reactions with alkynes for labeling and bioconjugation.
• Proteomics Research: Functions as a cross-linking agent or affinity tag for studying protein-protein interactions and post-translational modifications.
• Polymer and Materials Science: Acts as a functional monomer or cross-linker in the synthesis of smart hydrogels, surface coatings, and functionalized nanomaterials.
• Diagnostic Reagent Synthesis: Employed in the construction of fluorescent probes, imaging agents, and biosensor components.

Basic Information

Product Name	Phthalamide-Peg3-Azide
CAS No.	134179-44-5
Molecular Formula	C17H23N5O6
Molecular Weight	393.40 g/mol
Synonyms	2,5-Dioxopyrrolidin-1-yl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propyl (1,3-dioxoisoindolin-2-yl)acetate; Phthalamido-PEG3-azide; N-(3-Azidopropyl)-N'-(phthalimido)-triethyleneglycol; Azido-PEG3-phthalimide; PEG3-azide phthalamide linker; 1-Phthalimido-3-azido-PEG3; 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(1,3-dioxoisoindolin-2-yl)acetate
EINECS	Contact for details

Quality Control

Our Phthalamide-Peg3-Azide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and FT-IR for functional group verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and cGMP-grade material standards for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.