Description

2-[2-[2-[2-[(tert-Butyldimethylsilanyl)Oxy]Ethoxy]Ethoxy]Ethoxy]Ethanol is a specialized, high-purity polyethylene glycol (PEG) derivative featuring a terminal tert-butyldimethylsilyl (TBDMS) protecting group. This compound is critical for synthetic chemists as it provides a versatile, protected linker for the controlled functionalization of molecules, particularly in sensitive applications like oligonucleotide and peptide synthesis. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, biotechnology, and advanced materials sectors for constructing complex molecular architectures.

Application

• Solid-Phase Oligonucleotide Synthesis: Serves as a key building block for introducing hydrophilic, spacer, or linker functionalities into oligonucleotide sequences.
• Peptide Synthesis & Bioconjugation: Used as a protected PEG spacer to modify peptides, enhancing solubility, stability, and pharmacokinetic properties.
• Polymer & Dendrimer Chemistry: Acts as a functional monomer or chain extender for creating precisely engineered polymers with tailored properties.
• Surface Modification & Functionalization: Employed to create hydrophilic, non-fouling coatings on surfaces for biomedical devices and sensors.
• Crosslinking Agent: Utilized in the preparation of hydrogels and other crosslinked polymeric networks for controlled release applications.
• Intermediate for Advanced Materials: A crucial precursor in the synthesis of complex ligands, catalysts, and specialty surfactants.

Basic Information

Product Name	2-[2-[2-[2-[(tert-Butyldimethylsilanyl)Oxy]Ethoxy]Ethoxy]Ethoxy]Ethanol
CAS No.	134179-40-1
Molecular Formula	C16H36O6Si
Molecular Weight	352.55 g/mol
Synonyms	TBDMS-PEG4-OH; 2,5,8,11-Tetraoxatetradecan-14-ol, 14-[(1,1-dimethylethyl)dimethylsilyl]-; tert-Butyldimethylsilyl-PEG4-alcohol; 14-[(tert-Butyldimethylsilyl)oxy]-2,5,8,11-tetraoxatetradecan-14-ol; TBDMS-O-(CH2CH2O)4-H; TBDMS-protected tetraethylene glycol; Hydroxy-PEG4-TBDMS; (tert-Butyldimethylsiloxy)ethoxyethoxyethoxyethanol
EINECS	Contact for details

Quality Control

Our 2-[2-[2-[2-[(tert-Butyldimethylsilanyl)Oxy]Ethoxy]Ethoxy]Ethoxy]Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP principles where applicable, supporting its use in advanced research and regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.