Description

11-Azido-3,6,9-trioxaundecan-1-amine is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive amine group and an azide terminus. This compound matters as a versatile building block for bioconjugation and click chemistry, enabling the precise modification of biomolecules, surfaces, and polymers. It is primarily needed by researchers and manufacturers in pharmaceutical development, biotech, and materials science for creating targeted drug delivery systems, diagnostic probes, and functionalized hydrogels.

Application

• Bioconjugation and PEGylation: Used to attach amine-containing drugs, peptides, or proteins to azide-functionalized molecules or surfaces via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Click Chemistry Reagent: Serves as a key intermediate for synthesizing complex molecular architectures, dendrimers, and polymer networks through efficient azide-based "click" reactions.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and chromatographic media with amine-reactive groups for subsequent biomolecule immobilization.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker for hydrogel formation and polymer modification, introducing both amine and azide reactivity.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the construction of ADC linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Diagnostic Probe Synthesis: Utilized in the preparation of fluorescent or radioactive probes for imaging and diagnostic applications.

Basic Information

Product Name	11-Azido-3,6,9-trioxaundecan-1-amine
CAS No.	134179-38-7
Molecular Formula	C8H18N4O3
Molecular Weight	218.25 g/mol
Synonyms	Azido-PEG3-amine; 3-Azidopropyl-PEG2-amine; 11-Azido-3,6,9-trioxaundecyl-1-amine; N-(2-(2-(2-Azidoethoxy)ethoxy)ethyl)propane-1,3-diamine; Amino-PEG3-azide; Amine-PEG3-N3; Azido-PEG-amine (MW ~218); Heterobifunctional PEG linker, amine-azide
EINECS	Contact for details

Quality Control

Our 11-Azido-3,6,9-trioxaundecan-1-amine undergoes rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to guarantee identity, purity, and functional integrity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request. We adhere to strict GMP and ISO 9001 principles in our manufacturing and quality management processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). For long-term storage under inert atmosphere, consider sealing under nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Functional Group Assay (Amine)	≥ 90%
Functional Group Assay (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.