Description

4-Chloro-D-Phenylalanine Methyl Ester is a chiral, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a crucial chiral building block and intermediate for the development of novel bioactive molecules, including enzyme inhibitors and peptide mimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex, optically active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a building block for constructing peptide analogs and small molecule libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Enzyme Inhibitor Synthesis: Serves as a precursor in the synthesis of compounds designed to inhibit specific enzymes, such as those involved in amino acid metabolism.
• Process Chemistry & Scale-up: Employed in the development and optimization of synthetic routes for active pharmaceutical ingredients (APIs) requiring the D-phenylalanine scaffold with specific halogen substitutions.
• Biochemical Research: Used in studies investigating amino acid transport, metabolism, and incorporation into non-natural peptides.
• Asymmetric Synthesis: A valuable starting material for chiral pool synthesis and the preparation of enantiomerically pure compounds for various applications.

Basic Information

Product Name	4-Chloro-D-Phenylalanine Methyl Ester
CAS No.	134166-72-6
Molecular Formula	C10H12ClNO2
Molecular Weight	213.66 g/mol
Synonyms	D-4-Chlorophenylalanine methyl ester; Methyl (R)-2-amino-3-(4-chlorophenyl)propanoate; (R)-Methyl 2-amino-3-(4-chlorophenyl)propanoate; Methyl D-4-chlorophenylalaninate; (2R)-2-Amino-3-(4-chlorophenyl)propanoic acid methyl ester; 4-Chloro-D-Phe-OMe; D-p-Chlorophenylalanine methyl ester
EINECS	Contact for details

Quality Control

Our 4-Chloro-D-Phenylalanine Methyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, chiral chromatography, and NMR, to verify identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.