Description

(1,4-Dioxa-Spiro[4.5]Dec-8-Yl)-Acetic Acid is a versatile spirocyclic building block and protected functional intermediate of significant value in advanced organic synthesis. Its core value lies in providing a rigid, oxygenated spirocyclic framework that can be strategically deprotected and further functionalized to create complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key precursor for active pharmaceutical ingredients (APIs) and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing complex drug candidates, particularly those requiring spirocyclic or bridged ring systems for enhanced biological activity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where its unique structure can contribute to new modes of action.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored thermal and mechanical properties.
• Ligand and Catalyst Development: The acetic acid moiety and spirocyclic core can be modified to create novel chiral ligands or organocatalysts for asymmetric synthesis.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value flavors, fragrances, and other specialty chemicals.
• Academic & R&D Laboratories: A valuable tool for methodological studies in organic chemistry, including ring-opening reactions and the exploration of new synthetic pathways.

Basic Information

Item	Details
Product Name	(1,4-Dioxa-Spiro[4.5]Dec-8-Yl)-Acetic Acid
CAS No.	134136-04-2
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	8-(Carboxymethyl)-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decane-8-acetic acid; (1,4-Dioxaspiro[4.5]dec-8-yl)acetic acid; Spiro[1,3-dioxolane-2,1'-cyclohexane]-8-acetic acid; 8-Acetic acid-1,4-dioxaspiro[4.5]decane; Protected 4-oxocyclohexanecarboxylic acid derivative; Ketal-protected cyclohexanone acetic acid
EINECS	Contact for details

Quality Control

Our (1,4-Dioxa-Spiro[4.5]Dec-8-Yl)-Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.