Description

Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1S- is a high-purity, chiral cyclobutane derivative serving as a critical advanced intermediate in modern organic synthesis. Its unique sterically constrained four-membered ring structure is essential for constructing complex molecules with specific three-dimensional configurations. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in areas requiring rigid, conformationally locked scaffolds.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the cyclobutane ring can enhance biological activity and stability.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials that benefit from strained ring systems.
• Asymmetric Catalysis: Serves as a precursor or ligand in the development of chiral catalysts for stereoselective transformations.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new cyclobutane-based reactions and ring-opening/expansion chemistry.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1S-
CAS No.	134111-63-0
Molecular Formula	C9H14O2
Molecular Weight	154.21 g/mol
Synonyms	(1S)-3-Ethylidene-2-methylcyclobutanecarboxylic acid methyl ester; Methyl (1S)-3-ethylidene-2-methylcyclobutanecarboxylate; [1S-(3E)]-3-Ethylidene-2-methylcyclobutanecarboxylic acid methyl ester; (1S,2S)-3-Ethylidene-2-methylcyclobutanecarboxylic acid methyl ester (stereoisomer); Chiral cyclobutane ester; 3-Ethylidene-2-methyl-cyclobutanecarboxylic acid methyl ester, (1S)-
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 3-Ethylidene-2-Methyl-, Methyl Ester, [1S- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chiral purity. Every lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.