Description

18-Naphthoyl-5,8,11,14-Eicosatetraenoic Acid Methyl Ester is a specialized synthetic eicosanoid derivative, a key intermediate in advanced biochemical research and pharmaceutical development. Its value lies in its role as a functionalized arachidonic acid analog, enabling precise studies on lipid signaling pathways and enzyme inhibition. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors focused on developing novel anti-inflammatory agents and studying eicosanoid metabolism.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel bioactive molecules targeting cyclooxygenase (COX) and lipoxygenase (LOX) enzymes.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study arachidonic acid metabolism and eicosanoid biosynthesis pathways.
• Medicinal Chemistry: Serves as a building block for structure-activity relationship (SAR) studies aimed at developing new anti-inflammatory and immunomodulatory drugs.
• Reference Standard: Employed as an analytical standard in HPLC and LC-MS methods for the quantification of related eicosanoid compounds in complex matrices.
• Lipidomics Research: A valuable tool for investigating the role of modified fatty acids in cellular signaling, membrane dynamics, and disease models.

Basic Information

Product Name	18-Naphthoyl-5,8,11,14-Eicosatetraenoic Acid Methyl Ester
CAS No.	133983-27-4
Molecular Formula	C32H38O3
Molecular Weight	470.64 g/mol
Synonyms	Methyl 18-(1-naphthoyloxy)-5Z,8Z,11Z,14Z-eicosatetraenoate; 18-(1-Naphthoyl)arachidonic Acid Methyl Ester; 18-Naphthoyl-AA Methyl Ester; 18-NAA Methyl Ester; 5,8,11,14-Eicosatetraenoic Acid, 18-(1-Naphthoyl)-, Methyl Ester; Arachidonic Acid Methyl Ester, 18-Naphthoyl Derivative; Eicosatetraenoic Acid Methyl Ester, 18-Naphthoyl Derivative
EINECS	Contact for details

Quality Control

Our production of 18-Naphthoyl-5,8,11,14-Eicosatetraenoic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, keep the primary container sealed within a secondary moisture-barrier bag. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solubility	Soluble in DMSO, DMF, chloroform, ethyl acetate

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.