Description

3-(4-Azidobenzyl)-4-Hydroxycoumarin is a specialized bifunctional organic compound that combines the photochemical properties of an azide with the biological activity of a coumarin derivative. This molecule matters for its utility as a versatile photoaffinity labeling agent and a key building block in chemical biology and materials science research. It is primarily needed by R&D chemists and scientists in the pharmaceutical, bioconjugation, and advanced materials sectors for probe development and surface functionalization studies.

Application

• Photoaffinity Labeling (PAL): A critical reagent for covalently capturing and identifying transient protein-ligand interactions or mapping binding sites upon UV light activation.
• Chemical Biology Probes: Serves as a core scaffold for synthesizing activity-based probes to study enzyme function and metabolic pathways in live cells.
• Surface Functionalization: Used to introduce photoreactive groups onto polymers, nanoparticles, or biosensor surfaces for subsequent coupling with biomolecules.
• Crosslinking Agent: Employed in materials science to create cross-linked polymer networks or hydrogels with light-triggered curing properties.
• Pharmaceutical Intermediate: Acts as a key synthetic intermediate in the research and development of novel therapeutic agents.
• Bioconjugation Chemistry: Facilitates the stable attachment of dyes, drugs, or other payloads to antibodies, proteins, or oligonucleotides.

Basic Information

Product Name	3-(4-Azidobenzyl)-4-Hydroxycoumarin
CAS No.	133950-79-5
Molecular Formula	C₁₆H₁₁N₃O₃
Molecular Weight	293.28 g/mol
Synonyms	4-Hydroxy-3-(4-azidobenzyl)-2H-chromen-2-one; 3-(p-Azidobenzyl)-4-hydroxycoumarin; 4-Hydroxy-3-[(4-azidophenyl)methyl]-2H-1-benzopyran-2-one; ABHC; Photoaffinity Coumarin Derivative; Azidobenzylhydroxycoumarin
EINECS	Contact for details

Quality Control

Our 3-(4-Azidobenzyl)-4-Hydroxycoumarin is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. For long-term storage under inert atmosphere, consider sealing under argon or nitrogen. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.