Description

D-Erythro-Pentofuranoside, Methyl 3-Azido-2,3-Dideoxy-5-o-[(1,1-Dimethylethyl)Diphenylsilyl]- is a high-purity, protected nucleoside derivative and a critical chiral building block in advanced organic synthesis. This compound is valued for its role in constructing complex carbohydrate and nucleoside analogs, where precise stereochemistry and functional group compatibility are paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel antiviral agents, oligonucleotide therapeutics, and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Serves as a protected precursor for the solid-phase synthesis of modified oligonucleotides and antisense molecules.
• Carbohydrate Chemistry: Used as a versatile building block for the synthesis of complex, unnatural sugars and glycomimetics.
• Chemical Biology Probes: The azido group enables bioorthogonal "click chemistry" for labeling and studying biological systems.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring specific sugar moieties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	D-Erythro-Pentofuranoside, Methyl 3-Azido-2,3-Dideoxy-5-o-[(1,1-Dimethylethyl)Diphenylsilyl]-
CAS No.	133908-22-2
Molecular Formula	C22H29N3O4Si
Molecular Weight	427.58 g/mol
Synonyms	Methyl 3-Azido-2,3-dideoxy-5-O-[(1,1-dimethylethyl)diphenylsilyl]-D-erythro-pentofuranoside; 3-Azido-2,3-dideoxy-5-O-(tert-butyldiphenylsilyl)-D-erythro-pentofuranoside methyl ester; TBDPS-protected 3-azido-2,3-dideoxy-D-ribofuranoside; 5-O-TBDPS-3-azido-2,3-dideoxy-D-ribofuranoside methyl ether; Azido TBDPS Ribofuranoside Derivative; 3-Azido-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-D-erythro-pentofuranoside Methyl Ester; Protected 3-Azido Riboside
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.