Description

m-Peg2-T-Butyl Ester is a specialized bifunctional PEG derivative featuring a tert-butyl ester-protected carboxylic acid group. This compound is engineered to serve as a versatile building block in organic synthesis and bioconjugation, offering controlled reactivity and enhanced solubility. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as linker synthesis, polymer modification, and prodrug development.

Application

• Pharmaceutical Intermediate: Acts as a key building block for synthesizing prodrugs and active pharmaceutical ingredients (APIs) with improved pharmacokinetic properties.
• Bioconjugation Linker: Used to create PEGylated conjugates for proteins, peptides, and antibodies, enhancing stability and reducing immunogenicity.
• Polymer Chemistry: Serves as a functional monomer or chain transfer agent in the synthesis of tailored, water-soluble polymers and hydrogels.
• Protecting Group Strategy: The acid-labile tert-butyl ester group provides a convenient protecting group for carboxylic acids in multi-step synthetic routes.
• Surface Modification: Employed to functionalize nanoparticles and other material surfaces with PEG chains for improved biocompatibility and stealth properties.
• Cross-linking Agent: Utilized in the formation of biodegradable or cleavable cross-links within polymeric networks for controlled release applications.

Basic Information

Item	Detail
Product Name	m-Peg2-T-Butyl Ester
CAS No.	133803-57-3
Molecular Formula	C13H26O6
Molecular Weight	278.34 g/mol
Synonyms	2-[2-(2-Methoxyethoxy)ethoxy]acetic acid tert-butyl ester; tert-Butyl 2-[2-(2-methoxyethoxy)ethoxy]acetate; mPEG2-t-butyl ester; α-Methoxy-ω-carboxy(t-butyl ester) triethylene glycol; TEG Monomethyl Ether t-Butyl Ester; PEG2 Methyl Ether t-Butyl Ester; 3,6,9-Trioxaundecanoic acid, 11-methoxy-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our m-Peg2-T-Butyl Ester is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. The product is stable under these conditions but should be kept away from strong acids and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.