Description

Benzene, 1-Bromo-3-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]- is a high-value, organosilicon-protected bromophenol derivative, serving as a critical protected intermediate in advanced organic synthesis. Its primary value lies in enabling precise, multi-step synthetic routes where the silyl ether group provides temporary protection for the phenolic hydroxyl, allowing selective functionalization at other reactive sites. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing substituted phenol cores.
• Agrochemical Synthesis: Used in the development and production of advanced herbicides, fungicides, and pesticides where the bromine and protected phenol functionalities are leveraged for further coupling reactions.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing sophisticated ligands used in transition metal catalysis, such as cross-coupling reactions.
• Material Science Research: Employed in the creation of novel organic monomers and polymers, where the silyl-protected group allows for controlled polymerization or post-polymerization modification.
• Chemical Biology Probe Development: Utilized as a building block for synthesizing molecular probes and tags, where the bromine acts as a handle for bioconjugation via palladium-catalyzed reactions.
• Academic and Industrial R&D: A versatile reagent for methodological development in organic chemistry, enabling research into new protective group strategies and C-C bond forming reactions.

Basic Information

Product Name	Benzene, 1-Bromo-3-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]-
CAS No.	133772-45-9
Molecular Formula	C22H23BrOSi
Molecular Weight	411.41 g/mol
Synonyms	3-Bromophenyl tert-Butyldiphenylsilyl Ether; 3-Bromo-1-[(tert-Butyldiphenylsilyl)oxy]benzene; 1-Bromo-3-[(tert-Butyldiphenylsilyl)oxy]benzene; 3-Bromophenol TBDPS Ether; tert-Butyl(3-bromophenoxy)diphenylsilane; TBDPS Ether of 3-Bromophenol; 3-Bromo-O-TBDPS-phenol; 3-Bromophenoxy-tert-butyldiphenylsilane
EINECS	Contact for details

Quality Control

Our production of Benzene, 1-Bromo-3-[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]- adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. Every lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong bases and should be kept away from such materials. For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.