Description

5-Bromotryptophan Ethyl Ester is a protected derivative of the essential amino acid tryptophan, featuring a bromine substituent on the indole ring. This compound is a crucial advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to incorporate brominated tryptophan analogs.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of enzyme inhibitors or receptor modulators.
• Bioconjugation & Probe Development: The bromine atom provides a handle for further functionalization via cross-coupling reactions, useful for creating fluorescent probes or affinity labels.
• Academic & Industrial R&D: Employed in chemical biology and organic synthesis research to explore new chemical entities and synthetic methodologies.

Basic Information

Product Name	5-Bromotryptophan Ethyl Ester
CAS No.	133766-36-6
Molecular Formula	C₁₃H₁₅BrN₂O₂
Molecular Weight	311.18 g/mol
Synonyms	Ethyl 5-Bromo-DL-tryptophanate; Ethyl 2-Amino-3-(5-bromo-1H-indol-3-yl)propanoate; 5-Bromo-DL-tryptophan ethyl ester; 5-Bromo-DL-tryptophan, ethyl ester; 5-Bromotryptophan, ethyl ester; DL-5-Bromotryptophan ethyl ester; (RS)-5-Bromotryptophan ethyl ester
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity. Our products undergo comprehensive analytical testing, including HPLC, NMR, and MS, to verify identity and purity. A Certificate of Analysis (COA) is provided with each shipment, detailing all relevant specifications. Our manufacturing processes are designed to meet the stringent requirements of GMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.