Description

(3S)-Hydroxy Simvastatin is a key pharmaceutical intermediate and active metabolite of the cholesterol-lowering drug Simvastatin. This compound matters significantly for its role in the research, development, and production of statin-based therapeutics, offering a direct pathway to the active form. It is primarily needed by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers engaged in cardiovascular drug synthesis and metabolic studies.

Application

• Pharmaceutical Intermediate: Critical synthesis building block for Simvastatin and related HMG-CoA reductase inhibitors.
• Active Pharmaceutical Ingredient (API) Research: Used in studies investigating the pharmacokinetics and metabolism of statin drugs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in enzymatic studies to understand the mechanism of action of cholesterol biosynthesis inhibitors.
• Process Development: Utilized in optimizing fermentation and synthetic routes for statin production.
• Formulation Development: Aids in the development of novel drug delivery systems for improved bioavailability.

Basic Information

Product Name	(3S)-Hydroxy Simvastatin
CAS No.	133645-46-2
Molecular Formula	C25H38O6
Molecular Weight	434.57 g/mol
Synonyms	Simvastatin Hydroxy Acid; (3S,5R)-7-[(1S,2S,6S,8S,8aR)-8-Hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid; L 645,164; MK 0733; Simvastatin β-Hydroxy Acid; (3S)-Dihydroxy Simvastatin; Open Acid Form of Simvastatin
EINECS	Contact for details

Quality Control

Our (3S)-Hydroxy Simvastatin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade pharmaceutical standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.