Description

(R)-(+)-n-Methoxymethyl-n-(Trimethylsilyl)Methyl-1-Phenylethylamine is a high-purity, chiral amine derivative featuring both methoxymethyl and trimethylsilylmethyl protecting groups. This compound serves as a versatile chiral building block and auxiliary in advanced organic synthesis, enabling the stereoselective construction of complex molecules. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to induce stereoselectivity in carbon-carbon bond-forming reactions, such as alkylations and aldol condensations.
• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of enantiomerically pure drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Ligand Precursor: Can be modified to create novel chiral ligands for asymmetric catalysis, including hydrogenation and cross-coupling reactions.
• Building Block for Specialty Chemicals: Employed in the production of advanced materials, agrochemicals, and other performance chemicals requiring specific stereochemistry.
• Academic and Process Chemistry Research: Utilized in methodological development for new synthetic routes and scaling up chiral transformations.

Basic Information

Item	Details
Product Name	(R)-(+)-n-Methoxymethyl-n-(Trimethylsilyl)Methyl-1-Phenylethylamine
CAS No.	133407-38-2
Molecular Formula	C15H27NOSi
Molecular Weight	265.47 g/mol
Synonyms	(R)-N-Methoxymethyl-N-[(trimethylsilyl)methyl]-1-phenylethanamine; (R)-(+)-N-Methoxymethyl-N-(trimethylsilylmethyl)-α-methylbenzylamine; (R)-N-Methoxymethyl-N-(trimethylsilylmethyl)-1-phenylethylamine; (R)-α-Methylbenzylamine N-methoxymethyl N-trimethylsilylmethyl derivative; (R)-N,N-Bis(methoxymethyl?trimethylsilylmethyl)-1-phenylethylamine (common descriptor); Chiral TMS-protected amine auxiliary; (R)-Methoxymethyl(trimethylsilylmethyl)amine derivative
EINECS	Contact for details

Quality Control

Our (R)-(+)-n-Methoxymethyl-n-(Trimethylsilyl)Methyl-1-Phenylethylamine is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and enantiomeric excess meet exacting standards. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.