Description

Succinimidyl 6-Boc-Hydrazinonicotinate CAS NO 133081-26-2 is a high-purity, heterobifunctional crosslinking reagent featuring a protected hydrazine group and an amine-reactive N-hydroxysuccinimide (NHS) ester. This compound is critical for the controlled conjugation of biomolecules, enabling the formation of stable amide bonds while offering orthogonal reactivity for subsequent modification. It is primarily utilized by researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science who require precise and reliable linker chemistry.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Synthesis: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies via its hydrazine moiety, which can target carbonyl groups or be deprotected for further reaction.
• Peptide and Protein Modification: Used to introduce protected hydrazine functionalities into peptides or proteins through NHS-ester chemistry for site-specific labeling or immobilization.
• Surface Functionalization: Enables the covalent attachment of biomolecules to sensor chips, nanoparticles, or other solid supports for diagnostic assay and biosensor development.
• Polymer Chemistry: Acts as a building block for synthesizing functionalized polymers with reactive handles for drug delivery systems or smart materials.
• Chemical Biology Probes: Facilitates the creation of activity-based probes and affinity tags for studying protein function and interactions in complex biological systems.
• Intermediate for Pharmaceutical Actives: Used in the multi-step synthesis of complex drug candidates requiring a bifunctional linker with orthogonal protecting groups.

Basic Information

Product Name	Succinimidyl 6-Boc-Hydrazinonicotinate
CAS No.	133081-26-2
Molecular Formula	C20H26N4O7
Molecular Weight	434.45 g/mol
Synonyms	6-((tert-Butoxycarbonyl)hydrazinyl)nicotinic acid N-hydroxysuccinimide ester; 6-(Boc-hydrazino)nicotinic acid succinimidyl ester; 6-(N-Boc-hydrazino)nicotinic acid N-succinimidyl ester; 2,5-Dioxopyrrolidin-1-yl 6-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-3-carboxylate; 6-(N-Boc-hydrazinyl)nicotinic acid NHS ester; Boc-HYNIC-OSu; Boc-HYNIC-NHS; S-6-Boc-HYNIC-NHS
EINECS	Contact for details

Quality Control

Our Succinimidyl 6-Boc-Hydrazinonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.