Description

1-(((3R,5As,6R,8As,9R,10S,12R,12Ar)-3,6,9-Trimethyldecahydro-12H-3,12-Epoxy[1,2]Dioxepino[4,3-I]Isochromen-10-Yl)Oxy)Propan-2-One is a complex organic compound featuring a unique polycyclic structure with an epoxy and dioxepino moiety, making it a valuable advanced intermediate for specialized synthesis. This compound is critical for research and development in pharmaceutical chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and complex natural product analogs. It serves the needs of advanced R&D laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors seeking high-purity building blocks for complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and synthesis of novel therapeutic agents, particularly in anti-infective or anti-inflammatory drug discovery.
• Agrochemical Research: Used in the development of new, high-performance active ingredients for crop protection with potentially novel modes of action.
• Fine Chemical Synthesis: Serves as a sophisticated precursor for creating complex fragrance molecules, flavors, or specialty polymers requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic synthesis, including catalysis and stereoselective transformation research.
• Process Chemistry Development: Used for scaling up synthetic routes and optimizing production processes for complex target molecules in pilot plants.

Basic Information

Product Name	1-(((3R,5As,6R,8As,9R,10S,12R,12Ar)-3,6,9-Trimethyldecahydro-12H-3,12-Epoxy[1,2]Dioxepino[4,3-I]Isochromen-10-Yl)Oxy)Propan-2-One
CAS No.	133050-87-0
Molecular Formula	C20H30O6
Molecular Weight	366.45 g/mol
Synonyms	Artemisinin derivative intermediate; 10-O-(2-Oxopropyl)dihydroartemisinin; 10-(2-Oxopropoxy)dihydroartemisinin; Dihydroartemisinin 10-propionate ketone; 10-Propionyl Ketone Dihydroartemisinin; 10-O-(1-Methyl-2-oxoethyl)dihydroartemisinin; (10R)-10-[(2-Oxopropyl)oxy]-dihydroartemisinin; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-(((3R,5As,6R,8As,9R,10S,12R,12Ar)-3,6,9-Trimethyldecahydro-12H-3,12-Epoxy[1,2]Dioxepino[4,3-I]Isochromen-10-Yl)Oxy)Propan-2-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profile analysis, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity (HPLC), and specific tests are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, the container headspace should be minimized after opening. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.