Description

Carbamic Acid, [(1S)-1-(Fluorocarbonyl)-2-Methylpropyl]-, 1,1-Dimethylethyl Ester is a specialized chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing peptide mimetics and other high-value targets.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of protease inhibitors, enzyme inhibitors, and other novel active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to introduce fluorinated and tert-butoxycarbonyl (Boc)-protected amino acid motifs into peptide analogs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing advanced herbicides and pesticides with chiral specificity.
• Material Science Precursor: Potential use in the synthesis of specialized polymers and coatings requiring fluorinated components.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and labeled compounds for mechanistic studies.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring high-purity, optically active intermediates.

Basic Information

Product Name	Carbamic Acid, [(1S)-1-(Fluorocarbonyl)-2-Methylpropyl]-, 1,1-Dimethylethyl Ester
CAS No.	133010-02-3
Molecular Formula	C10H18FNO3
Molecular Weight	219.26 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-methylbutanoic acid fluoride; N-Boc-L-valine fluoride; Boc-L-Val-F; tert-Butyl ((2S)-1-fluoro-3-methyl-1-oxobutan-2-yl)carbamate; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoyl fluoride; Boc-Val-F; (2S)-2-[(tert-Butoxycarbonyl)amino]-3-methylbutanoyl fluoride; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-, fluoride
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1S)-1-(Fluorocarbonyl)-2-Methylpropyl]-, 1,1-Dimethylethyl Ester adheres to stringent in-process controls to ensure batch-to-batch consistency and high optical purity. Every lot is fully characterized by NMR, HPLC, and chiral analysis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile and moisture-sensitive nature, containers should be kept sealed under an inert atmosphere when not in use and away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.