Description

(2S)-2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidine is a high-purity, chiral pyrrolidinone derivative featuring a tert-butyldiphenylsilyl (TBDPS) protecting group, making it a critical advanced intermediate in sophisticated organic synthesis. Its primary value lies in enabling the precise construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and other fine chemicals where stereochemical integrity is paramount. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality building blocks for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those containing pyrrolidine or proline-like motifs.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and protease inhibitors due to its lactam functionality and protected hydroxymethyl side chain.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material for asymmetric transformations to introduce stereocenters in target molecules.
• Natural Product Synthesis: Employed as a building block in the total synthesis of complex natural products with biological activity.
• Agrochemical Development: Used in the research and development of novel, chiral active ingredients for crop protection.
• Material Science Precursor: Can be utilized in the synthesis of specialized polymers or ligands for catalysis.

Basic Information

Product Name	(2S)-2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidine
CAS No.	132974-83-5
Molecular Formula	C22H29NO2Si
Molecular Weight	367.56 g/mol
Synonyms	(S)-2-((tert-Butyldiphenylsilyloxy)methyl)-5-pyrrolidinone; (2S)-2-((tert-Butyldiphenylsilyloxy)methyl)-2-pyrrolidin-5-one; (S)-2-((TBDPS-oxy)methyl)-γ-butyrolactam; (S)-N-Boc-2-((tert-butyldiphenylsilyloxy)methyl)pyrrolidine-5-one; TBDPS-protected (S)-2-(hydroxymethyl)-5-pyrrolidinone; (S)-2-[[(tert-Butyldiphenylsilyl)oxy]methyl]-5-oxopyrrolidine; (S)-5-Oxo-1-pyrrolidine-2-methanol, TBDPS ether.
EINECS	Contact for details

Quality Control

Our (2S)-2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-5-Oxo-1-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.