Description

4-o-Acetyl-3,6-Di-o-(tert-Butyldimethylsilyl)-D-Glucal is a key protected carbohydrate intermediate, specifically a silyl-protected glucal derivative. This compound is essential for its role as a versatile chiral building block in the stereoselective synthesis of complex natural products and pharmaceuticals. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel glycosylation methodologies and bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleoside analogs, antiviral agents, and other glycosylated active pharmaceutical ingredients (APIs).
• Glycochemistry Research: Serves as a protected donor or acceptor in glycosylation reactions for constructing complex oligosaccharides and glycoconjugates.
• Chiral Pool Synthesis: Utilized as a source of chirality for the asymmetric synthesis of natural products and specialty chemicals.
• Agrochemical Development: Used in the research and production of novel, biologically active carbohydrate-based agrochemicals.
• Process Chemistry: Employed in route scouting and optimization for scalable manufacturing of carbohydrate-derived compounds.

Basic Information

Product Name	4-o-Acetyl-3,6-Di-o-(tert-Butyldimethylsilyl)-D-Glucal
CAS No.	132891-79-3
Molecular Formula	C22H44O6Si2
Molecular Weight	460.75 g/mol
Synonyms	D-Glucal, 4-O-acetyl-3,6-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-; 3,6-Di-O-tert-butyldimethylsilyl-4-O-acetyl-D-glucal; 4-O-Acetyl-3,6-di-O-(tert-butyldimethylsilyl)-D-glucal; 4-Acetoxy-3,6-bis-O-(tert-butyldimethylsilyl)-D-glucal; TBDMS-protected D-glucal acetate; Protected Glucal Derivative; Carbohydrate Silyl Ether Intermediate
EINECS	Contact for details

Quality Control

Our 4-o-Acetyl-3,6-Di-o-(tert-Butyldimethylsilyl)-D-Glucal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.